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Table 3 Autism candidate genes with known roles in neurite outgrowth and guidance.

From: A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

Function

Candidate gene (by lowest P-value)

Cadherin-catenin function

CDH8, CDH2, CDH11, CTNNB1, CTNNA2, PKP4, CTNND2, CDH4, CTNND1, CTNNA3

Cell adhesion

NCAM2, CNTN3, OPCML, ODZ4, NID1, CNTN5, F3, PVRL1, PTPRG, PARVA, FLRT2, ODZ2, NRXN1, ITGA9, ELMO1, FUT9, AMIGO2, KIRREL3, CNTNAP2, NTM

Ion channel

CACNA1I, CACNA1G

Axon guidance

SEMA4D, RTN4R, ROBO2, SEMA5A, PLXDC2, SLITRK5, SEMA6A, RGMA, UNC5D, ALCAM, NTNG2, RTN4RL1, PLXNC1, NRP2

Vesicle transport

STX2, STX16, STXBP5, SYT6

Post-synaptic scaffold

DLGAP2, MAGI1, MAGI2

Signal transduction

DNER, SPRY4, FRK, PRKCA, DOK6, PDE3A, FER, IRS2, SOCS2, SPRY2, FRS3, DOK5, FYN, LZTS1, PTPRD, FGFR2, NRG3, PPP2R2B ALK, RYR2, PALM2-AKAP2, MAP3K7, NTRK3, NGF, PPM1H, GDNF, CXCR4, PTK2, NEDD9, PTPN1, LEPR

Phosphatidylinositol signalling

PLA2G6, PIK3C2B, PTEN, PLA2G4A

Cell polarity

FAT1, PARD3, PARD6G, DCHS2

Rho-GTPase signalling

NCK2, DOCK1, PREX1, CDC42EP4, RND3, RGNEF, DOCK8, CIT, SRGAP3, KALRN, IQGAP2

Cytoskeletal regulation

SGK1, MYLK, GPR56, APBB1IP, PTPRM, WIPF3, PTPRT, MAP3K8, MICAL2, DGKG, COBL, CALD1

Transcription

PUM2, A2BP1, NKX6-1, SOX14, EN2, EBF1, MAP3K1, FOXG1, NFIC, BCL11A