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Table 3 Autism candidate genes with known roles in neurite outgrowth and guidance.

From: A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

Function Candidate gene (by lowest P-value)
Cadherin-catenin function CDH8, CDH2, CDH11, CTNNB1, CTNNA2, PKP4, CTNND2, CDH4, CTNND1, CTNNA3
Cell adhesion NCAM2, CNTN3, OPCML, ODZ4, NID1, CNTN5, F3, PVRL1, PTPRG, PARVA, FLRT2, ODZ2, NRXN1, ITGA9, ELMO1, FUT9, AMIGO2, KIRREL3, CNTNAP2, NTM
Ion channel CACNA1I, CACNA1G
Axon guidance SEMA4D, RTN4R, ROBO2, SEMA5A, PLXDC2, SLITRK5, SEMA6A, RGMA, UNC5D, ALCAM, NTNG2, RTN4RL1, PLXNC1, NRP2
Vesicle transport STX2, STX16, STXBP5, SYT6
Post-synaptic scaffold DLGAP2, MAGI1, MAGI2
Signal transduction DNER, SPRY4, FRK, PRKCA, DOK6, PDE3A, FER, IRS2, SOCS2, SPRY2, FRS3, DOK5, FYN, LZTS1, PTPRD, FGFR2, NRG3, PPP2R2B ALK, RYR2, PALM2-AKAP2, MAP3K7, NTRK3, NGF, PPM1H, GDNF, CXCR4, PTK2, NEDD9, PTPN1, LEPR
Phosphatidylinositol signalling PLA2G6, PIK3C2B, PTEN, PLA2G4A
Cell polarity FAT1, PARD3, PARD6G, DCHS2
Rho-GTPase signalling NCK2, DOCK1, PREX1, CDC42EP4, RND3, RGNEF, DOCK8, CIT, SRGAP3, KALRN, IQGAP2
Cytoskeletal regulation SGK1, MYLK, GPR56, APBB1IP, PTPRM, WIPF3, PTPRT, MAP3K8, MICAL2, DGKG, COBL, CALD1
Transcription PUM2, A2BP1, NKX6-1, SOX14, EN2, EBF1, MAP3K1, FOXG1, NFIC, BCL11A