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Table 3 Linkage results with P-values ≤ 0.0017 (suggestive evidence) for at least one method of analysis from quantitative and qualitative analyses of the total Social Responsiveness Score (SRS).

From: Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees

Chromosome Location1 Score (alpha2; P-value) Phenotype, model
6p25.3 133,969 1.93 (0.40; 0.0014) Qualitative, recessive
6p22.1 26,261,314 2.36 (0.31; 0.00049) Qualitative, recessive
7q31.1-q32.3 113,934,453 2.07 (0.54; 0.001) Quantitative, parametric
  129,451,548 2.91 (--; 0.00013) Quantitative, NPL
  130,291,151 2.55 (0.37; 0.00031) Qualitative, recessive
9p24.33 593,192 2.66 (0.75; 0.00023) Quantitative, parametric
10p12.1 27,770,267 2.03 (0.74; 0.0011) Qualitative, dominant
10q22.1-q22.2 76,287,863 1.88 (0.65; 0.0016) Qualitative, dominant
11p15.1-p15.44 12,519,296 2.77 (0.44; 0.00018) Quantitative, parametric
13q12.3 30,070,594 2.23 (0.60; 0.00068) Qualitative, recessive
13q32.1 94,452,168 2.14 (0.85; 0.00085) Qualitative, recessive
15q13.3 31,177,959 3.64 (--; 0.000021) Qualitative, NPL
  31,177,959 3.07 (0.70; 0.000085) Qualitative, recessive
19q13.43 59,338,102 2.14 (0.71; 0.00085) Quantitative, parametric
  1. Bold font indicates significant evidence (P ≤ 0.000048).
  2. Note: All nonparametric linkage (NPL) scores have been converted to equivalent logarithm of the odds (LOD) scores. Chromosomal locations indicated in italics overlap our affected-only genome scan using clinical diagnosis [32].
  3. 1 Location at the maximum of the peak.
  4. 2 Alpha, the estimated proportion of linked families for the MCLINK heterogeneity LOD score, is given for parametric analyses.
  5. 3 The peak at 9p24.3 is in the same location as a peak reported in a single family from our sample [35].
  6. 4 The peak at 11p15.1-p15.4 replicates previous genome scan results of quantitative SRS scores [20].