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Table 3 Linkage results with P-values ≤ 0.0017 (suggestive evidence) for at least one method of analysis from quantitative and qualitative analyses of the total Social Responsiveness Score (SRS).

From: Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees

Chromosome

Location1

Score (alpha2; P-value)

Phenotype, model

6p25.3

133,969

1.93 (0.40; 0.0014)

Qualitative, recessive

6p22.1

26,261,314

2.36 (0.31; 0.00049)

Qualitative, recessive

7q31.1-q32.3

113,934,453

2.07 (0.54; 0.001)

Quantitative, parametric

 

129,451,548

2.91 (--; 0.00013)

Quantitative, NPL

 

130,291,151

2.55 (0.37; 0.00031)

Qualitative, recessive

9p24.33

593,192

2.66 (0.75; 0.00023)

Quantitative, parametric

10p12.1

27,770,267

2.03 (0.74; 0.0011)

Qualitative, dominant

10q22.1-q22.2

76,287,863

1.88 (0.65; 0.0016)

Qualitative, dominant

11p15.1-p15.44

12,519,296

2.77 (0.44; 0.00018)

Quantitative, parametric

13q12.3

30,070,594

2.23 (0.60; 0.00068)

Qualitative, recessive

13q32.1

94,452,168

2.14 (0.85; 0.00085)

Qualitative, recessive

15q13.3

31,177,959

3.64 (--; 0.000021)

Qualitative, NPL

 

31,177,959

3.07 (0.70; 0.000085)

Qualitative, recessive

19q13.43

59,338,102

2.14 (0.71; 0.00085)

Quantitative, parametric

  1. Bold font indicates significant evidence (P ≤ 0.000048).
  2. Note: All nonparametric linkage (NPL) scores have been converted to equivalent logarithm of the odds (LOD) scores. Chromosomal locations indicated in italics overlap our affected-only genome scan using clinical diagnosis [32].
  3. 1 Location at the maximum of the peak.
  4. 2 Alpha, the estimated proportion of linked families for the MCLINK heterogeneity LOD score, is given for parametric analyses.
  5. 3 The peak at 9p24.3 is in the same location as a peak reported in a single family from our sample [35].
  6. 4 The peak at 11p15.1-p15.4 replicates previous genome scan results of quantitative SRS scores [20].
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Molecular Autism

ISSN: 2040-2392