Figure 3

Forest Plots of the six most significant markers from the transmission disequilibrium test (TDT) analyses. (a) rs1488454 (LRRN1); (b) rs12054065 (LRRN1); (c) rs10261004 (LRRN3); (d) rs1998753 (LRRTM3); (e) rs12266823 (LRRTM3); and (f) rs10997476 (LRRTM3). For each marker, the results for each population and for the overall meta-analysis TDT are represented. The population's labels correspond respectively to: German, ND (Northern Dutch), Italian, singleton families (IMGSAC) and multiplex families (IMGSAC). For each marker, the odds ratio (OR) is represented on the x-axis, and on the y-axis is shown the point estimate and its 95% confidence interval (CI). The overall meta-analysis estimate and its CI are at the bottom, represented as a diamond (indicating the pooled point estimate). The size of the black square represents the amount of data analysed for each population. The vertical bold line shows the no effect point (OR = 1) and the dotted line shows the overall effect point.