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Table 4 Genetic score sensitivities and specificities predicting autism in siblings of affected children.

From: Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk

Genetic score AGRE sample Seattle sample
  Sensitivity (95% CI) Specificity (95% CI) Sensitivity (95% CI) Specificity (95% CI)
2* 1.00 0.00 1.00 0.00
3 0.99 (0.98 to 1.00) 0.02 (0.00 to 0.03) 0.99 (0.97 to 1.00) 0.01 (0.00 to 0.03)
4 0.94 (0.92 to 0.97) 0.06 (0.03 to 0.09) 0.95 (0.92 to 0.98) 0.04 (0.00 to 0.07)
5 0.81 (0.76 to 0.86) 0.26 (0.21 to 0.31) 0.81 (0.75 to 0.87) 0.26 (0.18 to 0.35)
6 0.50 (0.44 to 0.56) 0.67 (0.61 to 0.73) 0.50 (0.43 to 0.57) 0.65 (0.55 to 0.74)
7 0.19 (0.14 to 0.25) 0.91 (0.87 to 0.96) 0.17 (0.12 to 0.22) 0.93 (0.87 to 0.98)
8 0.09 (0.05 to 0.12) 0.98 (0.96 to 1.00) 0.08 (0.04 to 0.12) 0.98 (0.96 to 1.00)
  1. AGRE, Autism Genetic Resource Exchange; CI, confidence interval.
  2. aReference group.