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Table 2 Linkage signals for insistence on sameness (IS) and repetitive sensory-motor actions (RSMA).

From: Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders

Chromosome Marker Boundary (Mb) Phenotype Rec Dom NPL
2p25.3-p25.1 rs309276 4.11 to 8.13 IS-Adj 2.12 - 2.56
2p25.2-p25.1 rs1560382 4.58 to 9.97 IS 2.00 - 2.56
2q37.1-q37.3 rs1569125 230.89 to 241.89 RSMA -- 2.15 -
2q37.1-q37.3 rs1198823 235.61 to 239.02 IS-Adj -- 2.02 2.57
2q37.1-q37.3 rs1198823 235.61 to 240.61 IS 2.22 3.42** 2.99
3q13.31-q22.1 rs13975 115.07 to 133.09 RSMA-Adj -- 2.02 -
4q31.22-q32.2 rs538317 146.67 to 162.95 IS-Adj 2.39 - 2.91
4q31.23-q32.2 rs2090870 150.39 to 163.91 IS 2.35 - -
6q22.31-q24.3 rs1041480 125.57 to 148.01 IS -- - 2.69
8q13.2-q22.1 rs1025908 68.59 to 97.25 RSMA-Adj -- 1.93 -
8q13.2-q22.1 rs2016354 70.19 to 96.31 RSMA -- 2.34 -
9p24.3-p24.1 rs1532309 0.59 to 4.80 IS 2.71 - -
13q12.12-q12.3* rs306395 22.86 to 30.07 IS 2.15 - 2.76
15q13.1-q14† rs904951 27.94 to 31.72 RSMA 3.93 2.68 4.54
15q13.1-q14 rs904951 27.94 to 31.72 RSMA-Adj 4.35 2.19 4.11
15q13.1-q15.1 rs965471 27.94 to 39.04 IS-Adj 2.05 - -
15q13.3-q15.1 rs965471 29.46 to 38.23 IS 2.00 - -
15q21.1-q22.2 rs11856 43.47 to 60.20 IS 1.88 - 2.60
15q21.2-q22.2 rs11856 50.79 to 59.13 IS-Adj 3.03 - 3.10
17p13.2-p13.1 rs1848550 5.23 to 9.00 RSMA 2.05 - -
17q23.2-q24.2 rs1874087 58.03 to 65.40 RSMA-Adj 2.40 - -
22q13.1-q13.33 rs132817 37.83 to 48.44 RSMA-Adj -- 1.98 -
Xp11.4-q21.33 rs763554 40.14 to 97.88 RSMA 2.61 - -
Xq13.1-q21.33 rs763554 70.24 to 96.70 RSMA-Adj 3.07 - -
Xq27.3-q28 rs17318101 142.53 to 154.55 RSMA 1.86 - -
Xq27.3-q28 rs473491 144.27 to 154.55 IS 1.97 - -
  1. Dom, dominant; Rec, recessive; IS, insistence on sameness; IS-Adj, IS adjusted for RSMA; RSMA, repetitive sensory-motor actions; RSMA-Adj, RSMA adjusted for IS.
  2. *The nonparametric linkage signal on chromosome 13 for IS shifted slightly downstream: 13q12.12-q13.1, marker = rs1886204, region boundaries = 22.86 to 31.54 Mb.
  3. †The dominant model signal on chromosome 15 for RSMA shifted slightly downstream: 15q13.1-q14, marker = rs2596156, region boundaries = 25.85 to 35.33 Mb.
  4. 'Adj', scale adjusted for the other scale. Signals that are least suggestive [60] are shown for parametric models; for nonparametric linkage (NPL), signals shown are regions where P < 0.005. Bold font for HLOD scores indicates genome-wide significance [60] and for NPL indicates P < 2E-05. Signal boundaries were defined as 1 HLOD or 1 NPL drops from the peak. If linkage at a locus was observed for more than one analysis, boundaries shown are for the recessive model.