|
Chromosome
|
Marker
|
Boundary (Mb)
|
Phenotype
|
Rec
|
Dom
|
NPL
|
|---|
|
2p25.3-p25.1
|
rs309276
|
4.11 to 8.13
|
IS-Adj
|
2.12
|
-
|
2.56
|
|
2p25.2-p25.1
|
rs1560382
|
4.58 to 9.97
|
IS
|
2.00
|
-
|
2.56
|
|
2q37.1-q37.3
|
rs1569125
|
230.89 to 241.89
|
RSMA
|
--
|
2.15
|
-
|
|
2q37.1-q37.3
|
rs1198823
|
235.61 to 239.02
|
IS-Adj
|
--
|
2.02
|
2.57
|
|
2q37.1-q37.3
|
rs1198823
|
235.61 to 240.61
|
IS
|
2.22
|
3.42**
|
2.99
|
|
3q13.31-q22.1
|
rs13975
|
115.07 to 133.09
|
RSMA-Adj
|
--
|
2.02
|
-
|
|
4q31.22-q32.2
|
rs538317
|
146.67 to 162.95
|
IS-Adj
|
2.39
|
-
|
2.91
|
|
4q31.23-q32.2
|
rs2090870
|
150.39 to 163.91
|
IS
|
2.35
|
-
|
-
|
|
6q22.31-q24.3
|
rs1041480
|
125.57 to 148.01
|
IS
|
--
|
-
|
2.69
|
|
8q13.2-q22.1
|
rs1025908
|
68.59 to 97.25
|
RSMA-Adj
|
--
|
1.93
|
-
|
|
8q13.2-q22.1
|
rs2016354
|
70.19 to 96.31
|
RSMA
|
--
|
2.34
|
-
|
|
9p24.3-p24.1
|
rs1532309
|
0.59 to 4.80
|
IS
|
2.71
|
-
|
-
|
|
13q12.12-q12.3*
|
rs306395
|
22.86 to 30.07
|
IS
|
2.15
|
-
|
2.76
|
|
15q13.1-q14†
|
rs904951
|
27.94 to 31.72
|
RSMA
|
3.93
|
2.68
|
4.54
|
|
15q13.1-q14
|
rs904951
|
27.94 to 31.72
|
RSMA-Adj
|
4.35
|
2.19
|
4.11
|
|
15q13.1-q15.1
|
rs965471
|
27.94 to 39.04
|
IS-Adj
|
2.05
|
-
|
-
|
|
15q13.3-q15.1
|
rs965471
|
29.46 to 38.23
|
IS
|
2.00
|
-
|
-
|
|
15q21.1-q22.2
|
rs11856
|
43.47 to 60.20
|
IS
|
1.88
|
-
|
2.60
|
|
15q21.2-q22.2
|
rs11856
|
50.79 to 59.13
|
IS-Adj
|
3.03
|
-
|
3.10
|
|
17p13.2-p13.1
|
rs1848550
|
5.23 to 9.00
|
RSMA
|
2.05
|
-
|
-
|
|
17q23.2-q24.2
|
rs1874087
|
58.03 to 65.40
|
RSMA-Adj
|
2.40
|
-
|
-
|
|
22q13.1-q13.33
|
rs132817
|
37.83 to 48.44
|
RSMA-Adj
|
--
|
1.98
|
-
|
|
Xp11.4-q21.33
|
rs763554
|
40.14 to 97.88
|
RSMA
|
2.61
|
-
|
-
|
|
Xq13.1-q21.33
|
rs763554
|
70.24 to 96.70
|
RSMA-Adj
|
3.07
|
-
|
-
|
|
Xq27.3-q28
|
rs17318101
|
142.53 to 154.55
|
RSMA
|
1.86
|
-
|
-
|
|
Xq27.3-q28
|
rs473491
|
144.27 to 154.55
|
IS
|
1.97
|
-
|
-
|
- Dom, dominant; Rec, recessive; IS, insistence on sameness; IS-Adj, IS adjusted for RSMA; RSMA, repetitive sensory-motor actions; RSMA-Adj, RSMA adjusted for IS.
- *The nonparametric linkage signal on chromosome 13 for IS shifted slightly downstream: 13q12.12-q13.1, marker = rs1886204, region boundaries = 22.86 to 31.54 Mb.
- †The dominant model signal on chromosome 15 for RSMA shifted slightly downstream: 15q13.1-q14, marker = rs2596156, region boundaries = 25.85 to 35.33 Mb.
- 'Adj', scale adjusted for the other scale. Signals that are least suggestive [60] are shown for parametric models; for nonparametric linkage (NPL), signals shown are regions where P < 0.005. Bold font for HLOD scores indicates genome-wide significance [60] and for NPL indicates P < 2E-05. Signal boundaries were defined as 1 HLOD or 1 NPL drops from the peak. If linkage at a locus was observed for more than one analysis, boundaries shown are for the recessive model.
