Fig. 3

ECoG spectral activity of Nlgn2 KO mice and littermates during SD and/or recovery. (A) Relative spectral activity between 0.5 and 50 Hz during wake (top), SWS (middle), and PS (bottom) for the total 24-h. An enlargement of the SWS activity between 0.5 and 4 Hz is presented in the inset of the middle panel. The peak frequency of PS activity is also presented in the inset of the lower panel. (B) Relative spectral activity between 0.5 and 50 Hz during wake (top), SWS (middle), and PS (bottom) for the total 24-h and expressed as percentage of BL (C) Twenty-four-hour dynamics of relative activity presented for wake theta, alpha, and gamma frequency bands, and for SWS delta frequencies. Significant Genotype by Interval interactions were decomposed by planned comparisons and represented with different color datapoints. Significant main Genotype effects were decomposed by Tuckey’s post hoc tests in panels A and B, and illustrated with lines at the top of each graphs, or decomposed by planned comparisons in panel C and illustrated with a vertical line accompanied with a star. Red lines at the top of graphs and Nlgn2 KO red datapoints indicate significant differences (p < 0.05) between KO and WT mice. Nlgn2 KO mice orange datapoints indicate significant differences (p < 0.05) in comparison to HET mice. Black lines at the top of graphs, Nlgn2 KO datapoints in orange with a red contour, and stars (*) indicate significant differences (p < 0.05) between KO mice and all littermates. Dashed backgrounds represent the 6-h SD. Gray backgrounds represent the dark period. REC: 18-h recovery after SD