Fig. 2

Sleep architecture of Nlgn2 KO mice and littermates during a 6-h SD and 18-h recovery. (A) Percentage of time spent in wake, SWS, and PS for the total 24 h (left), the 12-h light period (middle), and the 12-h dark period (right). (B) Twenty-four-hour distribution of time spent in wake, SWS, and PS. (C) Mean duration of individual bouts (left) and number of individual bouts (right) of wake, SWS, and PS for the light and dark periods. (D) Time spent in SWS (top) and PS (bottom) during the 6-h SD. (E) Latency to initiate SWS (top) and PS (bottom) from the end of SD. (F) Accumulated difference in SWS (left) and PS (right) during SD/recovery from BL values. (G) SWS (top) and PS (bottom) recovery slopes evaluated from the 6th to the 12th intervals of corresponding data in panel F. Significant Genotype by Interval interactions were decomposed by planned comparisons and represented with different color datapoints. Significant Genotype by Light/dark period interactions and main Genotype effects were decomposed by planned comparisons and illustrated with lines accompanied by symbols. Nlgn2 KO mice red datapoints and # symbols indicate significant differences (p < 0.05) in comparison to WT mice. Nlgn2 KO mice orange datapoints and + signs indicate significant differences (p < 0.05) in comparison to HET mice. Nlgn2 KO mice datapoints in orange with a red contour and stars (*) indicate significant differences (p < 0.05) in comparison to both HET and WT mice. Dashed backgrounds represent the 6-h SD. Gray backgrounds represent the dark period. REC: 18-h recovery after SD